PRP, Platelet-Rich Plasma, is a popular application in cosmetic implementations today. Hair transplantation and PRP can be combined in two different ways. Generally, PRP mesotherapy is applied to the area after hair transplantation. This method is used in our clinic. The other way is to apply PRP during hair transplantation to prevent ischemia-reperfusion injury, and we recommend PRP-supported hair transplantation in mega session hair transplantation procedures.